Led by Dr. Alejandro Bertolet, our lab focuses on modeling biology and dosimetry for radiopharmaceutical therapy and, in general, radiotherapy treatments Contact us
Chamseddine I, Shah K, Lee H, Ehret F, Schuemann J, Bertolet A, Shih HA, and Paganetti H. “Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis.” Clinical Cancer Research, August 6, 2024. https://doi.org/10.1158/1078-0432.CCR-24-1215.
Bobić, M, Huesa-Berral C, Terry JF, Kunz LV, Schuemann J, Fisher DR, Maitz C, and Bertolet A. “Monte Carlo Dosimetric Analyses on the Use of 90 Y-IsoPet Intratumoral Therapy in Canine Subjects.” Physics in Medicine & Biology, July 25, 2024. https://doi.org/10.1088/1361-6560/ad67a4.
Meyer, I, Peters N, Tamborino G, Lee H, Bertolet A, Faddegon B, Mille M, Lee C, Schuemann J, and Paganetti H. “A Framework for In-Field and out-of-Field Patient Specific Secondary Cancer Risk Estimates from Treatment Plans Using the TOPAS Monte Carlo System.” Physics in Medicine & Biology, July 17, 2024. https://doi.org/10.1088/1361-6560/ad64b6.
Huesa-Berral C, Withrow JD, Dawson RJ, Beekman C, Bolch WE, Paganetti H, Wehrenberg-Klee E, and Bertolet A. “MIDOS: A Novel Stochastic Model towards a Treatment Planning System for Microsphere Dosimetry in Liver Tumors.” European Journal of Nuclear Medicine and Molecular Imaging 51, no. 6 (May 2024): 1506–15. https://doi.org/10.1007/s00259-023-06567-9.
2023
Díaz García-Prada C, Léna C, Atis S, Parach A, Bertolet A, Jarlier M, Poty S, Suarez-García D, Shin WG, Du Manoir S, Schuemann J, Tillement O, Lux F, Constanzo J, Pouget JP. Gadolinium-based nanoparticles sensitize ovarian peritoneal carcinomatosis to targeted radionuclide therapy. Journal of Nuclear Medicine 2023. https://doi.org/10.2967/jnumed.123.265418
Bertolet A, Chamseddine I, Paganetti H, Schuemann J. The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model. Frontiers in Oncology 2023, 13, p. 1196502. https://doi.org/10.3389/fonc.2023.1196502
Suárez-García D, Cortés-Giraldo MA, Bertolet A. A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness? Radiotherapy and Oncology, 2023, 185, p. 109730, https://doi.org/10.1016/j.radonc.2023.109730
Zhang Q, Gerweck LE, Cascio EW, Gu L, Yang Q, Dong X, Huang P, Bertolet A, Nesteruk KP, Sung W, McNamara AL, Schuemann J. Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine. Cancers 2023, 15(8), 2269, https://doi.org/10.3390/cancers15082269
Bobić M, Lalonde A, Nesteruk KP, Lee H, Nenoff L, Gorissen BL, Bertolet A, Busse PM, Chan AW, Winey BA, Sharp GC, Verburg JM, Lomax AJ, Paganetti H. Large anatomical changes in head-and-neck cancers – a dosimetric comparison of online and offline adaptive proton therapy. Clinical and Translational Radiation Oncology. 31 March 2023, 100625. https://doi.org/10.1016/j.ctro.2023.100625
Zhang Q, Gerweck LE, Cascio EW, Yang Q, Huang P, Niemierko A, Bertolet A, Nesteruk KP, McNamara AL, Schuemann J. Proton FLASH effects on mouse skin at different oxygen tensions. Phys Med Biol. 2023 Feb 2. PMID: 36731139, https://doi.org/10.1088/1361-6560/acb888
2022
Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon S, Paganetti H, Schuemann J. Impact of DNA geometry and scoring on Monte Carlo track-structure simulations of initial radiation-induced damage. Radiation Research. 2022; 198(3):207-22. https://doi.org/10.1667/RADE-21-00179.1
Miras H, Terrón JA, Bertolet A, Leal A. Modified Geometry of 106Ru Asymmetric Eye Plaques to Improve Dosimetric Calculations in Ophthalmic Brachytherapy. J Pers Med. 2022 Apr 29;12(5). PMID: 35629144, PMCID: PMC9144752, https://doi.org/10.3390/jpm12050723
Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A. Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):237-246. https://doi.org/10.1016/j.ijrobp.2021.08.027
2021
Bertolet A, Wehrenberg-Klee E, Bobic M, Grassberger C, Perl J, Paganetti H, Schuemann J. Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Phys Med Biol. 2021; 66 244002. https://doi.org/10.1088/1361-6560/ac43fd
Baratto-Roldán A, Bertolet A, Baiocco G, Carabe A, Cortés-Giraldo MA. Microdosimetry and dose-averaged LET calculations of protons in liquid water: a novel Geant4-DNA application. Frontiers in Physics. 2021 Oct 27 9:726787. https://doi.org/10.3389/fphy.2021.726787
Miras Del Río H, Ortiz Lora A, Bertolet Reina A, Terrón León JA. A Monte Carlo dose calculation system for ophthalmic brachytherapy based on a realistic eye model. Med Phys. 2021 Aug;48(8):4542-4559. PMID: 34250607, https://doi.org/10.1002/mp.15045
Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J. The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Phys Med Biol. 2021 Jul 30;66(15). PMID: 34280910, PMCID: PMC8483580, https://doi.org/10.1088/1361-6560/ac15a5
Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. Implementation of the microdosimetric kinetic model using analytical microdosimetry in a treatment planning system for proton therapy. Phys Med. 2021 Jan;81:69-76. PMID: 33440283, https://doi.org/10.1016/j.ejmp.2020.11.024
2020
Bertolet A, Wals A, Miras H, Macías J. Organic generation of real-world real-time data for clinical evidence in radiation oncology. Int J Med Inform. 2020 Dec;144:104301. PMID: 33091831, https://doi.org/10.1016/j.ijmedinf.2020.104301
Bertolet A, Grilj V, Guardiola C, Harken AD, Cortés-Giraldo MA, Baratto-Roldán A, Carabe A. Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a silicon-based microdosimeter. Radiat Phys Chem Oxf Engl 1993. 2020 Nov;176. PMID: 33100611, PMCID: PMC7583143, https://doi.org/10.1016/j.radphyschem.2020.109060
Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. An Analytical Microdosimetric Model for Radioimmunotherapeutic Alpha Emitters. Radiat Res. 2020 Oct 2;194(4):403-410. PMID: 33045091, https://doi.org/10.1667/RADE-20-00045.1
Bertolet A, Carabe-Fernandez A. Clinical implications of variable relative biological effectiveness in proton therapy for prostate cancer. Acta Oncol. 2020 Oct;59(10):1171-1177. PMID: 32427011, https://doi.org/10.1080/0284186X.2020.1762928
Bertolet A, Carabe A. Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model. Life (Basel). 2020 Aug 23;10(9). PMID: 32842519, PMCID: PMC7555955, https://doi.org/10.3390/life10090161
Bertolet A, Carabe A. Proton monoenergetic arc therapy (PMAT) to enhance LETd within the target. Phys Med Biol. 2020 Aug 19;65(16):165006. PMID: 32428896, https://doi.org/10.1088/1361-6560/ab9455
Carabe A, Karagounis IV, Huynh K, Bertolet A, François N, Kim MM, Maity A, Abel E, Dale R. Radiobiological effectiveness difference of proton arc beams versus conventional proton and photon beams. Phys Med Biol. 2020 Aug 31;65(16):165002. PMID: 32413889, https://doi.org/10.1088/1361-6560/ab9370
Bertolet A, Cortés-Giraldo MA, Souris K, Carabe A. A kernel-based algorithm for the spectral fluence of clinical proton beams to calculate dose-averaged LET and other dosimetric quantities of interest. Med Phys. 2020 Jun;47(6):2495-2505. PMID: 32124463, https://doi.org/10.1002/mp.14108
Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. On the concepts of dose-mean lineal energy, unrestricted and restricted dose-averaged LET in proton therapy. Phys Med Biol. 2020 Apr 2;65(7):075011. PMID: 32023557, https://doi.org/10.1088/1361-6560/ab730a
Carabe-Fernandez A, Bertolet-Reina A, Karagounis I, Huynh K, Dale RG. Is there a role for arcing techniques in proton therapy?. Br J Radiol. 2020 Mar 1;93(1107):20190469. PMID: 31860338, PMCID: PMC7066964, https://doi.org/10.1259/bjr.20190469
2019
Bertolet A, Cortés-Giraldo MA, Souris K, Cohilis M, Carabe-Fernandez A. Calculation of clinical dose distributions in proton therapy from microdosimetry. Med Phys. 2019 Dec;46(12):5816-5823. PMID: 31603992, https://doi.org/10.1002/mp.13861
Bertolet A, Baratto-Roldán A, Cortés-Giraldo MA, Carabe-Fernandez A. Segment-averaged LET concept and analytical calculation from microdosimetric quantities in proton radiation therapy. Med Phys. 2019 Sep;46(9):4204-4214. PMID: 31228264, https://doi.org/10.1002/mp.13673
Bertolet A, Baratto-Roldán A, Barbieri S, Baiocco G, Carabe A, Cortés-Giraldo MA. Dose-averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations. Med Phys. 2019 Sep;46(9):4184-4192. PMID: 31169910, https://doi.org/10.1002/mp.13643
