The multiscale pipeline

Dosimetry & Modeling for RPT

Open announcements (updated Oct 18, 2023)

About us: b-lab

Led by Dr. Alejandro Bertolet, our lab focuses on modeling biology and dosimetry for radiopharmaceutical therapy and, in general, radiotherapy treatments
Contact us


Alejandro Bertolet, PhD

Head, Assistant Professor of Radiation Oncology

FOCUS: Radiation biology, Radiopharmaceutical therapy, Mechanistic modeling

Permanent Members

Carlos Huesa-Berral, PhD

Postdoctoral Fellow

FOCUS: Microsphere transarterial radioembolization

Victor Valladolid-Onecha, PhD

Postdoctoral Fellow

FOCUS: Monte Carlo SPECT

Jesús Bosque, PhD

Postdoctoral Fellow

FOCUS: Mathematical oncology, modeling

Mislav Bobić, PhD

Medical Physics Resident

FOCUS: Liver vasculature personalization for microsphere transarterial radioembolization


Gerardo Julián Ramírez Nava, PhD

Postdoctoral Fellow, Tecnológico de Monterrey

FOCUS: Dosimetry for 177Lu treatments

Zakiya Williams

Undergraduate Student – Howard University

FOCUS: Dosimetry for 161Tb treatments

Alex Culver

Undergraduate Student – Loyola University Chicago

FOCUS: Simulations of damage to vasculature

David Miao

Undergraduate Student – University of Toronto

FOCUS: Monte Carlo simulations

PAST Members

Louis Kunz

M.Sc. Student – ETH Zürich (Switzerland)

FOCUS: Tumor dynamics and radiation response

Jack Terry

Undergrad Student – Auburn University

FOCUS: Microscale dose distributions

José A. López-Valverde

Ph.D. Student – Universidad de Sevilla (Spain)

FOCUS: Radiosensitizer nanoparticles

Héctor Miras

Ph.D. Student – Universidad de Sevilla (Spain)

FOCUS: Monte Carlo simulations, nanoparticles

Seohan Kim

M.Sc. Student -Catholic University of Korea (South Korea)

FOCUS: Diffusive alpha-particle radiotherapy

Daniel Suárez

Ph.D. Student – Universidad de Sevilla (Spain)

FOCUS: Microdosimetric simulations

MJ Lindsey

Undergrad Student – Claremont McKenna College

FOCUS: Biologically weighted dose in Y90 treatments

Ben Edwards

Research Assistant

FOCUS: DNA repair after alpha-particle RPT

Our Research

News and Events


Huesa-Berral C, Withrow JD, Dawson RJ, Beekman C, Bolch WE, Paganetti H, Wehrenberg-Klee E, Bertolet A. MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors. Eur J Nucl Med Mol Imaging. 2023 Dec 29. doi: 10.1007/s00259-023-06567-9. Epub ahead of print. PMID: 38155237.
Díaz García-Prada C, Léna C, Atis S, Parach A, Bertolet A, Jarlier M, Poty S, Suarez-García D, Shin WG, Du Manoir S, Schuemann J, Tillement O, Lux F, Constanzo J, Pouget JP. Gadolinium-based nanoparticles sensitize ovarian peritoneal carcinomatosis to targeted radionuclide therapy. Journal of Nuclear Medicine 2023.
Bertolet A, Chamseddine I, Paganetti H, Schuemann J. The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model. Frontiers in Oncology 2023, 13, p. 1196502.
Suárez-García D, Cortés-Giraldo MA, Bertolet A. A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness? Radiotherapy and Oncology, 2023, 185, p. 109730,
Zhang Q, Gerweck LE, Cascio EW, Gu L, Yang Q, Dong X, Huang P, Bertolet A, Nesteruk KP, Sung W, McNamara AL, Schuemann J. Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine. Cancers 2023, 15(8), 2269,
Bobić M, Lalonde A, Nesteruk KP, Lee H, Nenoff L, Gorissen BL, Bertolet A, Busse PM, Chan AW, Winey BA, Sharp GC, Verburg JM, Lomax AJ, Paganetti H. Large anatomical changes in head-and-neck cancers – a dosimetric comparison of online and offline adaptive proton therapy. Clinical and Translational Radiation Oncology. 31 March 2023, 100625.
Zhang Q, Gerweck LE, Cascio EW, Yang Q, Huang P, Niemierko A, Bertolet A, Nesteruk KP, McNamara AL, Schuemann J. Proton FLASH effects on mouse skin at different oxygen tensions. Phys Med Biol. 2023 Feb 2. PMID: 36731139,
Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon S, Paganetti H, Schuemann J. Impact of DNA geometry and scoring on Monte Carlo track-structure simulations of initial radiation-induced damage. Radiation Research. 2022; 198(3):207-22.
Miras H, Terrón JA, Bertolet A, Leal A. Modified Geometry of 106Ru Asymmetric Eye Plaques to Improve Dosimetric Calculations in Ophthalmic Brachytherapy. J Pers Med. 2022 Apr 29;12(5). PMID: 35629144, PMCID: PMC9144752,
Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A. Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):237-246.
Bertolet A, Wehrenberg-Klee E, Bobic M, Grassberger C, Perl J, Paganetti H, Schuemann J. Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Phys Med Biol. 2021; 66 244002.
Baratto-Roldán A, Bertolet A, Baiocco G, Carabe A, Cortés-Giraldo MA. Microdosimetry and dose-averaged LET calculations of protons in liquid water: a novel Geant4-DNA application. Frontiers in Physics. 2021 Oct 27 9:726787.
Miras Del Río H, Ortiz Lora A, Bertolet Reina A, Terrón León JA. A Monte Carlo dose calculation system for ophthalmic brachytherapy based on a realistic eye model. Med Phys. 2021 Aug;48(8):4542-4559. PMID: 34250607,
Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J. The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Phys Med Biol. 2021 Jul 30;66(15). PMID: 34280910, PMCID: PMC8483580,
Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. Implementation of the microdosimetric kinetic model using analytical microdosimetry in a treatment planning system for proton therapy. Phys Med. 2021 Jan;81:69-76. PMID: 33440283,
Bertolet A, Wals A, Miras H, Macías J. Organic generation of real-world real-time data for clinical evidence in radiation oncology. Int J Med Inform. 2020 Dec;144:104301. PMID: 33091831,
Bertolet A, Grilj V, Guardiola C, Harken AD, Cortés-Giraldo MA, Baratto-Roldán A, Carabe A. Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a silicon-based microdosimeter. Radiat Phys Chem Oxf Engl 1993. 2020 Nov;176. PMID: 33100611, PMCID: PMC7583143,
Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. An Analytical Microdosimetric Model for Radioimmunotherapeutic Alpha Emitters. Radiat Res. 2020 Oct 2;194(4):403-410. PMID: 33045091,
Bertolet A, Carabe-Fernandez A. Clinical implications of variable relative biological effectiveness in proton therapy for prostate cancer. Acta Oncol. 2020 Oct;59(10):1171-1177. PMID: 32427011,
Bertolet A, Carabe A. Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model. Life (Basel). 2020 Aug 23;10(9). PMID: 32842519, PMCID: PMC7555955,
Bertolet A, Carabe A. Proton monoenergetic arc therapy (PMAT) to enhance LETd within the target. Phys Med Biol. 2020 Aug 19;65(16):165006. PMID: 32428896,
Carabe A, Karagounis IV, Huynh K, Bertolet A, François N, Kim MM, Maity A, Abel E, Dale R. Radiobiological effectiveness difference of proton arc beams versus conventional proton and photon beams. Phys Med Biol. 2020 Aug 31;65(16):165002. PMID: 32413889,
Bertolet A, Cortés-Giraldo MA, Souris K, Carabe A. A kernel-based algorithm for the spectral fluence of clinical proton beams to calculate dose-averaged LET and other dosimetric quantities of interest. Med Phys. 2020 Jun;47(6):2495-2505. PMID: 32124463,
Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. On the concepts of dose-mean lineal energy, unrestricted and restricted dose-averaged LET in proton therapy. Phys Med Biol. 2020 Apr 2;65(7):075011. PMID: 32023557,
Carabe-Fernandez A, Bertolet-Reina A, Karagounis I, Huynh K, Dale RG. Is there a role for arcing techniques in proton therapy?. Br J Radiol. 2020 Mar 1;93(1107):20190469. PMID: 31860338, PMCID: PMC7066964,
Bertolet A, Cortés-Giraldo MA, Souris K, Cohilis M, Carabe-Fernandez A. Calculation of clinical dose distributions in proton therapy from microdosimetry. Med Phys. 2019 Dec;46(12):5816-5823. PMID: 31603992,
Bertolet A, Baratto-Roldán A, Cortés-Giraldo MA, Carabe-Fernandez A. Segment-averaged LET concept and analytical calculation from microdosimetric quantities in proton radiation therapy. Med Phys. 2019 Sep;46(9):4204-4214. PMID: 31228264,
Bertolet A, Baratto-Roldán A, Barbieri S, Baiocco G, Carabe A, Cortés-Giraldo MA. Dose-averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations. Med Phys. 2019 Sep;46(9):4184-4192. PMID: 31169910,

The Physics Division Labs

Paganetti Lab

Head: Harald Paganetti, PhD

Research Areas: Proton Therapy & Immune Response

Schuemann Lab

Head: Jan Schuemann, PhD

Research Areas: Monte Carlo & FLASH

Chamseddine Lab

Head: Ibrahim Chamseddine, PhD

Research Areas: Outcome & Machine learning

Nesteruk Lab

Head: Konrad Nesteruk, PhD

Research Area: R&D in Particle Therapy

Optimization Lab

Head: Thomas Bortfeld, PhD

Research Areas: Optimization in RadOnc


Head: Yi Wang, PhD

Research Area: Artificial Intelligence in RadOnc

Proton Dosimetry & Verification

Head: Joost Verburg, PhD

Research Area: Proton




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