Developing tumor models that simulate dynamics and evolution, including the effects of angiogenesis, radiation-induced vascular damage, interstitial pressure, extracellular factors, and cell-scale interactions, is essential in cancer research. By considering the complex interplay between various cell subpopulations and microenvironmental factors, these models provide a comprehensive understanding of tumor growth and treatment response. This enhanced understanding enables researchers to develop more effective therapies and personalized approaches, ultimately improving cancer patient outcomes.