We are thrilled to announce that we held our first meeting yesterday with the University of Pennsylvania, marking the commencement of an inspiring collaboration. Our teams are eager to dedicate their expertise towards a crucial R01 project: “Optimizing theranostic radiopharmaceutical therapy to combat resistance to PARP inhibition in advanced ovarian cancer.” This collaboration is a […]
Our postdoctoral fellow, Carlos Huesa Berral, has been awarded with the ‘Best-In-Physics’ distinction at the American Association of Physicists in Medicine (AAPM) annual conference, which will take place in Houston, TX, next July. This meeting is one of the biggest and most important in Medical Physics in the world, and Carlos’ outstanding work on MIDOS,
Best-In-Physics award at AAPM conference for our postdoc Carlos Huesa Read More »
We recently developed a groundbreaking tool named MIDOS, aimed at revolutionizing liver cancer treatment through Transarterial Radioembolization (TARE). TARE is an innovative procedure where radioactive microspheres are injected into the liver’s arterial supply to target and destroy liver tumors while sparing healthy tissue. However, optimizing this treatment for each individual patient has remained a challenge
MIDOS: MIcrosphere DOSimetry for transarterial radioembolization Read More »
Simulating the diffusion of alpha-particle emitters in decay chains, such as Ra224, using the TOPAS toolkit is crucial for understanding the underlying mechanisms of diffusive alpha radiotherapy (DART). This process can result in daughter particles, like Pb-212, traveling millimeters away from the initial source, impacting the distribution of radiation dose. Accurate Monte Carlo-based dose calculations
Modeling diffusive alpha-particle radiation therapy Read More »
Developing tumor models that simulate dynamics and evolution, including the effects of angiogenesis, radiation-induced vascular damage, interstitial pressure, extracellular factors, and cell-scale interactions, is essential in cancer research. By considering the complex interplay between various cell subpopulations and microenvironmental factors, these models provide a comprehensive understanding of tumor growth and treatment response. This enhanced understanding
Simulating in vitro experiments under realistic conditions is crucial in radiopharmaceutical research, and Monte Carlo techniques using the TOPAS toolkit can provide valuable insights. These simulations account for changing exposure conditions due to binding affinity, internalization, secretion, physical decay, and cell-washing procedures. By closely mimicking actual experimental conditions, Monte Carlo simulations can help researchers study
DNA repair models that incorporate a repair “clock” are crucial in radiopharmaceutical therapy, as they account for the continuous radiation dose experienced by cells during treatment. These models consider the simultaneous processes of damage induction and repair, allowing for a more accurate prediction of cellular outcomes. By evaluating the remaining damage at specific cell cycle
ChronoRepair: modeling DNA repair and induction at the same time Read More »
