MEET THE PI
Dr. Alejandro Bertolet, PhD
Dr. Bertolet is an Assistant Professor of Radiation Oncology at Harvard Medical School, the Director of the Radiopharmaceutical Dosimetry Program at the Mass General Hospital, and a faculty on the Division of Physics at MGH Radiation Oncology. He is a medical physicist certified for clinical duties in Spain, and has expertise in mathematical and computational modeling, Monte Carlo simulations and the radiobiology of radiation therapy.
Alejandro completed his PhD studies at the Universidad de Sevilla (Spain), working as a scholar in the University of Pennsylvania, and since then has been a member of MGH, where he has obtained multiple NIH-funded projects. He is a member of the SNMMI MIRD Committee, the co-director of the RPT track for the AAPM annual meeting, and the current John D. Boice awardee by the NCRP.
Our current Lab Members
He builds computer and benchtop models that track how radioactive microspheres move through blood vessels and deposit dose. His goal: turn raw physics into treatment maps doctors can trust.
He writes the heavy-duty code that powers our microdosimetry and imaging. From GPU-accelerated SPECT recon to DNA repair time-lapse models, he turns billions of particle track into fast answers about risk and benefit.
She leads AMBER, an agent-based model that simulates whole populations of cancer and normal cells reacting to radiation. She tests how timing, fractionation, and micro-environment cues tilt the balance between cure and ciomoplication.
He explores how tiny helpers (nano-particles, radio-activatable pro-drugs, DNA-damage foci detectors) can make radiation hit harder or spare healthy tissue. He mixes wet-lab biology with image analysis software to see which tricks actually work in cells.
He develops patient-specific liver vasculature to see blood-dose studies that track radiation exposure to circulating cells. He also quantifies tracers like 64Cu-Macrin to show where immune cells cluster and how much the patient organs receive.
He mines Y-90 liver cancer cases, linking dose maps and other patient-specific features to real world tumor control and side effects. His analysis shape ho we adjust prescriptions for each patient.
He builds the ChronoRepair digital-twin of DNA-damage repair and uses of microdosimetry data to compare how different radiation qualities break tumor cells.
She extends the Microdsoimetric Gamma Model (MGM) so that a single track-structure run spits out a fast but-accurate RBE estimate, trimming days of compute from radiobiology studies.
He designs flow phantoms and Monte Carlo maps that predict where Y-90 microsphere lodge in each patient’s liver, guiding dose prescriptions and catheter placement.
She uses AMBER to produce synthetic images of virtual tumors, which allows us to compare how the tumor is simulated to evolve with real data.
She quantifies microsphere clustering in Oncopig liver tumors: histology, PET scans, and fluid-dynamics data that ground-truth our radioembolization models.
She curates the DNA-damage literature and benchmarks ChronoRepair against published survival curves, keeping the code honest and the datasets reproducible.
She studies the mechanisms of action of radiosensitizing nanoparticles in ovarian cancer, and helps developing predictive models to optimize this therapeutic strategy.
He works on physiology-based pharmacokinetic modeling to be applied to dosimetry for radiopharmaceutical therapy when imaging availability is limited.
He is working on mathematical models for drug transport across membranes, with special focus on the blood-brain barrier and radiopharmaceuticals for glioblastoma therapy.
LAB ALUMNI – from our lab to the world
Where are they now?
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Name and time of stay
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Current Position
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Socials
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|---|---|---|---|
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Daniel Suárez-García
October-December 2024
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PhD Student, Universidad de Sevilla
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Jesús Bosque
2023-2024
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Research, Univ Carlos III
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Peter Dukakis
June-August 2024
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Undergrad Student, UC San Diego
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Alex Culver
May-August 2024
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Undergrad Student, Loyola University Chicago
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David Miao
May-August 2024
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Undergrad Student, University of Toronto
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A. Sebastian Cuervo
June-August 2024
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Undergrad Student, Yale University
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Zakiya Williams
May-August 2024
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Undergrad Student, Howard University
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Marina García-Cardosa
December 2023-May 2024
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Ph.D. Student, Universidad de Navarra
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G. Julián Ramírez Nava
January-June 2024
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Postdoctoral Fellow, Politecnico Monterrey
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Louis Kunz
February-August 2023
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Ph.D. Student, University of Geneve
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Jack Terry
May-August 2023
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Master Student, LSE
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Héctor Miras del Rio
March-May 2023
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Medical Physicist, Hospital Virgen Macarena
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Seohan Kim
April 2023
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Ph.D. Student, Catholic University of Korea
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Ben Edwards
October 2022-June 2023
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Graduate Student, UMass Lowell
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Marcus (MJ) Lindsay
May-August 2022
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Ph.D. Student, University of Wisconsin-Madison
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100 Blossom St, Cox 802D & 125 Nashua St,
Boston, MA, 02141
The Bertolet Lab
at the Mass General Hospital
