2025

• Space- and time-defined Monte Carlo dosimetry explains ovarian cancer cell viability in targeted alpha-particle therapy with [211At]PTT

  Onecha VV, Suarez-Garcia D, Bosque JJ, Lee H, Simpkins F, Gitto SB, Pryma DA, Bertolet A. Int J Radiat Oncol Biol Phys (2025). Accepted. Background: Radiopharmaceutical Therapy (RPT) aims to irradiate tumors using antibodies or small molecules chelated with radioisotopes that target tumor cells. The biological response resulting from the complex interplay between radioisotope decay…

• In response to Yu and Chen: Proton FLASH-Arc Therapy: Bridging feasibility to clinical utility

  Rothwell B, Bertolet A, Schuemann J. Radiotherapy and Oncology (2024). We sincerely appreciate the insightful comments from Yu and Chen [1] regarding our recent study on Proton FLASH-Arc Therapy (PFAT) [2]. It is encouraging to see the interest in this proposed modality, and we welcome the opportunity to further discuss key aspects of dose-rate optimization,…

• Dosimetrically coupled multiscale tetrahedral mesh models of human liver vasculature: implications for radiopharmaceutical dosimetry of both organ blood and parenchyma

  Dawson RJ, Huesa-Berral C, Carter L, Beekman C, Choi C, Shin B, Bobić M, Cogno N, Withrow JD, Jokisch DW, et al. Phys Med Biol (2025). Purpose: To develop a computational framework coupling multiscale vascular models of the human liver for improved radiation dosimetry calculations that clearly distinguish the absorbed dose to tissue parenchyma and…

• Exploring biochemical considerations for diffusive alpha radiation therapy (DaRT) models

  Dukakis P, Bosque JJ, Bertolet A. Physica Medica (2025). Diffusing alpha-emitting Radiation Therapy (DaRT) is a cancer treatment currently undergoing clinical trials. DaRT utilizes localized 224-Radium (224Ra) seeds to deliver high linear energy transfer (LET) alpha radiation. Its main advantage over other alpha radiation treatments is that the diffusion of 224Ra decay chain products allows…

• Real-time dose reconstruction in proton therapy from in-beam PET measurements

  Onecha VV, Espinosa-Rodriguez A, Soneira-Landín C, Arias-Valcayo F, Gaitán-Dominguez S, Martinez-Nouvilas V, García-Díez M, Ibáñez P, España S, Sanchez-Parcerisa D, et al. Phys Med Biol (2025). Objective. Clinical implementation of in-beam positron emission tomography (PET) monitoring in proton therapy (PT) requires the integration of an online fast and reliable dose calculation engine. This manuscript reports…

• Review of the geometrical developments in GEANT4-DNA: from a biological perspective

  Khanna R, Reinwald Y, Hugtenburg R, Bertolet A, Serjouei A. Reviews in Physics (2025). GEANT4-DNA is an expansion of the widely utilised GEANT4 Monte Carlo toolkit. This extension focuses on modelling the physical, chemical, and biological stages of ionising radiation for radiobiological applications at cellular and DNA level interactions. To date, review papers on GEANT4-DNA…

• Sequencing microsphere selective internal radiotherapy after external beam radiotherapy for hepatocellular carcinoma: proof of concept of a synergistic combination

  Huesa-Berral C, Terry JF, Kunz L, Bertolet A. British Journal of Radiology (2025). Objectives:This study aims to explore the synergistic effects of combining stereotactic body radiation therapy (SBRT) and selective internal radiation therapy (SIRT) in that specific sequence for treating hepatocellular carcinoma (HCC), particularly in patients at high risk of radiation-induced liver disease (RILD). Methods:We…

• Localized In Vivo Prodrug Activation Using Radionuclides

  Quintana JM, Jiang F, Kang M, Valladolid Onecha V, Könik A, Qin L, Rodriguez VE, Hu H, Borges N, Khurana I, et al. J Nucl Med (2025) Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides…

• SPECT/CT Dosimetry of Bronchial Artery99m Tc Macroaggregated Albumin Injection in Pulmonary Malignancies: Feasibility Evaluation of Bronchial Artery 90Y Radioembolization

  Wehrenberg-Klee E, An T, Heidari P, Huesa-Berral C, Dreher MR, Eldridge A, Fowers K, Schuemann J, Bertolet A. Radiology (2025) SPECT/CT dosimetric analysis of technetium 99m macroaggregated albumin injected via the bronchial artery for pulmonary malignancy suggests that bronchial artery yttrium 90 radioembolization could be an alternative treatment for patients unable to receive external beam…

• Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study

  Shin W-G, D-Kondo JN, Ramos-Méndez J, LaVerne JA, Rothwell B, Bertolet A, McNamara A, Faddegon B, Paganetti H, Schuemann J. Phys Med Biol (2025) Objective. TOPAS-nBio enables users to simulate dose rate-dependent radiation chemical yields in water radiolysis accounting for inter-track and long-term chemistry for pulsed irradiation. This study aims to extend the TOPAS-nBio chemistry…

• Prognostic Role of Patient, Tumour and Radiomic Factors Influencing Outcomes in Dogs With Thyroid Cancer Treated With Iodine‐131

  Chamseddine I, Cowan C, Donnelly L, Abergel RJ, Schuemann J, Bertolet A, Maitz CA. Vet Comparative Oncology (2025) Radioactive iodine therapy (I-131) is widely used in both human and veterinary medicine for treating thyroid cancer, utilising the common biological behaviour of thyroid tissues. Recognising the need to better understand the prognostic factors affecting heterogeneous treatment…

2024

• Monte Carlo dosimetric analyses on the use of 90Y-IsoPet intratumoral therapy in canine subjects

  Bobić M, Huesa-Berral C, Terry JF, Kunz L, Schuemann J, Fisher DR, Maitz CA, Bertolet A. Phys Med Biol (2024). Objective. To investigate different dosimetric aspects of 90Y-IsoPet™ intratumoral therapy in canine soft tissue sarcomas, model the spatial spread of the gel post-injection, evaluate absorbed dose to clinical target volumes, and assess dose distributions and…

• A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system

  Meyer I, Peters N, Tamborino G, Lee H, Bertolet A, Faddegon B, Mille MM, Lee C, Schuemann J, Paganetti H. Phys Med Biol (2024). Objective. To allow the estimation of secondary cancer risks from radiation therapy treatment plans in a comprehensive and user-friendly Monte Carlo (MC) framework. Method. Patient planning computed tomography scans were extended…

• Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis

  Chamseddine I, Shah K, Lee H, Ehret F, Schuemann J, Bertolet A, Shih HA, Paganetti H. Clinical Cancer Research (2024). Purpose:In radiotherapy (RT) for brain tumors, patient heterogeneity masks treatment effects, complicating the prediction and mitigation of radiation-induced brain necrosis. Therefore, understanding this heterogeneity is essential for improving outcome assessments and reducing toxicity. Experimental Design:We…

• AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response

  Kunz LV, Bosque JJ, Nikmaneshi M, Chamseddine I, Munn LL, Schuemann J, Paganetti H, Bertolet A. Bull Math Biol (2024). Computational models of tumor growth are valuable for simulating the dynamics of cancer progression and treatment responses. In particular, agent-based models (ABMs) tracking individual agents and their interactions are useful for their flexibility and ability…

• FLIP: a novel method for patient-specific dose quantification in circulating blood in large vessels during proton or photon external beam radiotherapy treatments

  García-Cardosa M, Meiriño R, Calvo FA, Antolín E, Aguilar B, Vidorreta M, Cuevas R, Barbés B, Huesa-Berral C, Azcona J-D, et al. Phys Med Biol (2024). Purpose. To provide a novel and personalized method (FLIP, FLow and Irradiation Personalized) using patient-specific circulating blood flows and individualized time-dependent irradiation distributions, to quantify the dose delivered to…

• Proton FLASH-arc therapy (PFAT): A feasibility study for meeting FLASH dose-rate requirements in the clinic

  Rothwell B, Bertolet A, Schuemann J. Radiotherapy and Oncology (2024) Background and purposeProton arc therapy and FLASH radiotherapy (FLASH-RT) each offer unique advantages in proton therapy. However, clinical translation of FLASH-RT faces challenges in defining and delivering high dose rates. We propose the use of proton FLASH-arc therapy (PFAT) to leverage the benefits of arc…

• MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors

  Huesa-Berral C, Withrow JD, Dawson RJ, Beekman C, Bolch WE, Paganetti H, Wehrenberg-Klee E, Bertolet A. Eur J Nucl Med Mol Imaging (2024) Purpose: Transarterial radioembolization (TARE) procedures treat liver tumors by injecting radioactive microspheres into the hepatic artery. Currently, there is a critical need to optimize TARE towards a personalized dosimetry approach. To this…